TOMA Lab Referee for the consortium:
dr.ssa P.H.D. Francesca Romana Grati
Reserarch and development department director
ISCA is a consortium created by laboratories and experts in cytogenetics and molecular cytogenetics that use array platforms (CGH, SNP and with suspended spheres). The aims of ISCA consortium are the following: 1) assessing the clinical utility of these platforms: ISCA will make recommendations about which are the most appropriate clinical indications for the use of the array platforms. Currently the debated issue is the application, in the paediatric field, in idiopathic cases of retardation of motor development, mental retardation, autism and other disabilities. It is programmed the creation of a commission for the discussion of possible applications in the field of genetics of tumours. 2) looking for a common standard based on clinical evidence: ISCA will make recommendations on the standards for the resolution and the regions to investigate through these platforms. A group of international experts will be involved (geneticists, clinics, representatives of laboratories of cytogenetics and molecular cytogenetics, experts in genomics and bioinformatics).
This shared plan will be independent from the kind of platform used and from the manufacturer (only the coordinates of the suggested sequences to be investigated will be given) and will involve a dynamic process that is constantly evolving and updating: all these changes will be examined by all the experts involved.